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February 28, 2026Ultrasonics SonochemistryOpen Access

Ultrasound-assisted deep eutectic solvent extraction of ginseng folium polysaccharides: Extraction mechanism, process optimization, structural characterization, and in vitro biological activity

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Authors

WYWeijie YangHeilongjiang University of Chinese MedicineSJShuang JiangHarbin Medical UniversityXWXiaotian WuHarbin Medical University

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Implication

Develops an efficient extraction method for ginseng folium polysaccharides, suggesting improved yields and biological activity.

Key Points

  • The aim is to develop an efficient and green extraction method for ginseng folium polysaccharides using ultrasound-assisted deep eutectic solvents.
  • Screened 17 deep eutectic solvent systems to find the optimal solvent.
  • Optimized extraction parameters using Plackett–Burman and Box–Behnken methodologies.
  • Compared polysaccharide characteristics among hot water extraction, ultrasound-assisted extraction, and ultrasound-assisted deep eutectic solvent extraction.
  • Choline chloride-lactic acid was identified as the optimal solvent.
  • UA-DES method achieved a significantly lower molecular weight (361.70 kDa) compared to other methods.
  • Different extraction methods influenced the monosaccharide composition and biological activities, impacting antioxidant and α-glucosidase inhibition.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69a286eb0a974eb0d3c02486https://doi.org/10.1016/j.ultsonch.2026.107797
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