What question did this study set out to answer?

This research aims to clarify the diagnostic challenges in distinguishing Takotsubo syndrome from hypertrophic obstructive cardiomyopathy.

February 28, 2026BMJ Case Reports

Diagnostic challenges of Takotsubo syndrome in the context of hypertrophic obstructive cardiomyopathy phenocopy

Q: What does this research mean for the field?

Cardiac MRI effectively differentiates Takotsubo syndrome from hypertrophic obstructive cardiomyopathy by identifying transient hypertrophic cardiomyopathy phenocopy and left ventricular outflow tract obstruction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

cMRI identifies transient HCM phenocopy and LV outflow obstruction in Takotsubo syndrome to exclude HOCM.

Why the study?

The diagnosis of Takotsubo syndrome may be challenging in daily clinical practice.

Population

One patient presenting with acute anterolateral ST elevation myocardial infarction and non-obstructive coronary arteries

Design

Case report

Authors

FBFanni Bánfi-BacsárdiUniversity of Szeged ZFZsolt ForraiUniversity of Szeged ZPZsolt PiróthInterventional Cardiology

Discussion

Member takes

Implication

CMR differentiates TTS from HOCM phenocopy in MINOCA with LVOTO; extends diagnostic precision and leaves open need for larger validation.

Key Points

This research aims to clarify the diagnostic challenges in distinguishing Takotsubo syndrome from hypertrophic obstructive cardiomyopathy.
Evaluated patient with ST elevation myocardial infarction and non-obstructive coronary arteries.
Used transthoracic echocardiography and sequential cardiac MRI for diagnosis.
Implemented guideline-directed medical therapy for treatment.
Cardiac MRI confirmed Takotsubo syndrome diagnosis and excluded HOCM.
Patient demonstrated transient hypertrophic cardiomyopathy phenocopy and LVOTO.
Significant improvement in clinical status and ejection fraction was observed post-treatment.

Structured PICO

Population

1 patient presenting with an initial diagnosis of acute anterolateral ST elevation myocardial infarction, non-obstructive coronary arteries, and suspected hypertrophic obstructive cardiomyopathy (HOCM) and Takotsubo syndrome.

Intervention

Cardiac MRI (cMRI) and guideline-directed medical therapy

Outcome

Differential diagnosis between Takotsubo syndrome and HOCM

Cardiac MRI is a crucial modality for differentiating Takotsubo syndrome from hypertrophic obstructive cardiomyopathy phenocopy in patients presenting with acute myocardial infarction and non-obstructive coronary arteries.

Cite This Study

Bánfi-Bacsárdi et al. (2026) studied this question. Cardiac MRI identified transient hypertrophic cardiomyopathy phenocopy and LV outflow obstruction in Takotsubo syndrome, aiding accurate diagnosis and exclusion of HOCM.

synapsesocial.com/papers/69a287010a974eb0d3c02629 https://doi.org/10.1136/bcr-2025-270318

Topics

Takotsubo Syndrome Hypertrophic cardiomyopathy

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Diagnostic challenges of Takotsubo syndrome in the context of hypertrophic obstructive cardiomyopathy phenocopy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Diagnostic challenges of Takotsubo syndrome in the context of hypertrophic obstructive cardiomyopathy phenocopy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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