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February 28, 2026Journal of Drug Research in Ayurvedic SciencesOpen Access

Nephroprotective effect of Swadamstradi Ghana: A dried aqueous decoction of Ayurvedic polyherbal formulation on gentamicin-induced kidney damage in rats

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Authors

DSDubey SonamEVE. N. T. VikramPYPramod Yadav

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Overview

Investigates the nephroprotective effects of Swadamstradi Ghana in rats with kidney damage, suggesting potential benefits for renal health.

Key Points

  • To evaluate the nephroprotective effects of Swadamstradi Ghana against gentamicin-induced kidney damage in rats.
  • Induced nephrotoxicity in Wistar albino rats through gentamicin administration.
  • Divided rats into six groups for treatment comparison.
  • Assessed renal function using serum creatinine, blood urea nitrogen, malondialdehyde, and histopathology.
  • Statistical analysis performed with one-way ANOVA and Dunnett’s post hoc test.
  • Gentamicin significantly elevated creatinine, BUN, and MDA levels.
  • SG at 300 mg/kg reduced creatinine levels to normal ranges.
  • SG treatment also significantly lowered BUN and MDA levels.
  • Histopathology revealed reduced tubular damage and maintained glomerular architecture.

Cite This Study

Sonam et al. (2026) studied this question.

synapsesocial.com/papers/69a287b00a974eb0d3c0387ahttps://doi.org/10.4103/jdras.jdras_18_25
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