Associations between pulse pressure amplification and inflammation in young adults according to body composition: The African-PREDICT study

Abstract Pulse pressure amplification (PPA) is a measure of arterial function and wave reflection dynamics. The potential contribution of low-grade systemic inflammation to PPA—particularly in the context of overweight and obesity (OW/OB)—remains unclear, especially in young adults. We assessed differences in PPA and inflammatory markers (leptin, interleukin-6, interleukin-8, tumour necrosis factor-α, adiponectin, interleukin-10, and C-reactive protein) in young adults stratified by body composition. We further determined the relationship of PPA and inflammatory markers within these groups. This cross-sectional study included 1202 adults aged between 20-30 years. Participants were stratified into groups with underweight ( N = 82) healthy weight ( N = 598), overweight ( N = 326) and obesity ( N = 196). PPA was defined as the ratio of brachial pulse pressure to central pulse pressure. Inflammatory biomarkers were measured in serum. PPA was lower in the OW and OB groups ( p < 0.001), while the inflammatory profile (tumour necrosis factor-α, adiponectin, leptin and C-reactive protein) was also more adverse in the OW and OB groups (all p < 0.001). In multivariate adjusted regression analysis, PPA was adversely associated with tumour necrosis factor-α, adiponectin, leptin and C-reactive protein in the OW or OB groups only (all p < 0.025). In young adults, a higher BMI is associated with a lower PPA and higher levels of inflammatory markers. Adverse associations between PPA as a measure of arterial function and several inflammatory markers are also seen in the setting of increased adiposity, highlighting inflammation as a potential mechanistic link between adiposity and changes in arterial function.