Abstract Introduction An expanded portfolio of more effective WHO-prequalified insecticides for indoor residual sparing (IRS) is needed to provide additional options to disease control programmes and enhance their capacity to efficiently apply IRS rotations for managing vector resistance to insecticides. We investigated the efficacy and residual activity of Sovrenta® 15WP, a wettable powder formulation of the newly discovered isoxazoline insecticide isocycloseram, (active ingredient trademarked as PLINAZOLIN® technology) for IRS in laboratory bioassays and experimental hut studies. Methods Sovrenta® 15WP, was evaluated under laboratory conditions for 12 months at the dose of 120 mg a.i./m 2 on cement, mud and wood block substrates against insecticide-susceptible Anopheles gambiae sensu stricto Kisumu and pyrethroid-resistant An. gambiae sensu lato (s.l.) Covè strains. An experimental hut trial was also performed to investigate its efficacy and residual activity on cement and mud-plastered walls at the target dose of 120 mg a.i./m 2 over 12 months against wild free-flying pyrethroid-resistant An. gambiae sl at the Covè experimental hut station in Benin. Mosquito mortality was recorded every 24 h for up to 168 h post-exposure. Sovrenta® 15 WP was compared to Actellic® 300CS, a WHO/PQ-listed pirimiphos-methyl IRS insecticide applied at 1000 mg a.i./m 2 Results In laboratory cone bioassays, Sovrenta® 15WP induced > 80% mortality of susceptible and pyrethroid-resistant An. gambiae sl for 11–12 months on cement, mud and wood block substrates. A total of 12,850 wild pyrethroid-resistant An. gambiae s.l. were collected in the experimental hut trial. Sovrenta® 15WP induced significantly higher mosquito mortality in the experimental huts over 12 months compared to Actellic® 300CS (68–72% vs 44–46%, p 80% for 12 months with Sovrenta® 15WP and 9 months with Actellic® 300CS. Conclusion Sovrenta® 15WP provided extended control of pyrethroid-resistant malaria vectors when applied for IRS on local wall substrates. The insecticide presents a new effective IRS option for achieving improved malaria control and managing insecticide resistance through the rotation of IRS insecticides.
Govoétchan et al. (Fri,) studied this question.