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To explore the role of RhoGEF Trio in the regulation of endothelial cell activities during angiogenesis.

March 1, 2026Vascular BiologyOpen Access

Endothelial RhoGEF Trio is involved in angiogenesis

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To explore the role of RhoGEF Trio in the regulation of endothelial cell activities during angiogenesis.
Investigated endothelial cell sprouting in both in vitro and in vivo models.
Utilized embryonic zebrafish to assess the effects of Trio inhibition on vessel sprouting.
Performed murine retinal explant assays to analyze sprout length and development.
Conducted rescue experiments to identify which region of the Trio protein supports endothelial functions.
Inhibition of Trio activity significantly reduces sprout formation in embryonic zebrafish.
A marked decrease in the length of developing sprouts is observed in murine retinal explant assays.
Trio-/- mice exhibit severe vascular defects, indicating impaired angiogenesis.

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Experimental findings reveal Trio's essential role in promoting angiogenesis, indicating its importance in vascular development.

Kroon et al. (2026) studied this question.

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