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March 1, 20260 citationsOpen Access

Core Epithelial-to-Mesenchymal Transition Gene Signature Predicts Metastasis and Poor Survival in Synovial Sarcoma.

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MJMegan H. JagoskyCAColin AndersonNSNury Steuerwald

Key Points

  • The research aims to explore the relationship between epithelial-to-mesenchymal transition (EMT) gene signatures and metastasis in synovial sarcoma (SS).
  • Analyzed gene expression signatures from primary tumor samples at diagnosis
  • Assessed correlation between EMT status and metastatic risk
  • Evaluated the potential of EMT as a biomarker for prognosis
  • Found significant correlation between mesenchymal gene signatures and increased metastatic risk
  • Identified EMT status as a potential prognostic biomarker for synovial sarcoma
  • Suggested that EMT could help tailor treatment and surveillance strategies

Abstract

This study demonstrates a correlation between mesenchymal gene expression signatures and increased metastatic risk in SS. EMT status, derived from primary tumor profiling at diagnosis, may serve as a potential prognostic biomarker. These findings support further investigation into EMT as a stratification tool for tailoring treatment intensity and surveillance strategies in SS.

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Cite This Study

Jagosky et al. (2026) studied this question.

synapsesocial.com/papers/69a3d747ec16d51705d2dc57https://doi.org/10.1002/cam4.71643
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel candidate metastasis‐associated genes for synovial sarcoma2024 · 2 citations
  2. 2Periostin and Epithelial–Mesenchymal Transition Score as Novel Prognostic Markers for Leiomyosarcoma, Myxofibrosarcoma, and Undifferentiated Pleomorphic Sarcoma2020 · 16 citations
  3. 3Identification of EMT-related subtype and a 9 genes signature predicts the prognosis in osteosarcoma2025 · 1 citations
  4. 4Genetic Profiling of Primary Versus Metastatic Ewing Sarcoma for Therapeutic Target Identification2026
  5. 5Abstract PS2-10-18: Epithelial-mesenchymal transition (EMT) Signature Score of a Bulk Tumor May Not Reflect the EMT of Malignant Epithelial Cells2026