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March 1, 2026Medical Microbiology and ImmunologyOpen Access

Characterization of outer membrane vesicles from Acinetobacter haemolyticus and their role in the dissemination of carbapenem resistance

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Authors

EMElsy Martínez-GorgonioRRRosa del Carmen Rocha-GraciaMCMiguel Castañeda-Lucio

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Overview

This investigation shows how outer membrane vesicles convey carbapenem resistance genes, highlighting their clinical relevance.

Key Points

  • The research aims to characterize outer membrane vesicles (OMVs) from A. haemolyticus and explore their role in spreading carbapenem resistance.
  • Characterization of OMVs from A. haemolyticus AN54 and its plasmid-cured derivative AN54Δe
  • TEM imaging to observe OMV secretion and size
  • Protein profiling via mass spectrometry to identify resistance-related proteins
  • Assessment of OMV protective capabilities against antibiotic action.
  • OMVs ranged from 10-50 nm in size and were actively secreted by both strains
  • OMVs from AN54 showed hydrolytic activity against carbapenem
  • Variations in the OMV protein profile were noted based on antibiotic concentration
  • OMVs from AN54Δe contained higher levels of porins, efflux pumps, and ADC enzyme compared to AN54
  • OMVs enabled the transfer of the blaNDM−1-carrying plasmid, conferring permanent resistance to AN54Δe.

Cite This Study

Martínez-Gorgonio et al. (2026) studied this question.

synapsesocial.com/papers/69a3d79dec16d51705d2dec1https://doi.org/10.1007/s00430-026-00870-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Strain-specific outer membrane vesicle-mediated transfer of a bla OXA-24 -like plasmid in Acinetobacter baumannii restricts cross-species dissemination2026
  2. 2630. Protective Role of Outer Membrane Vesicles Released by Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates Against Carbapenems and Cefiderocol2026
  3. 3Characterization of the Outer Membrane Vesicles of Pseudomonas aeruginosa Exhibiting Growth Inhibition against Acinetobacter baumannii2024 · 7 citations
  4. 4Dynamics of a large multidrug-resistant plasmid encoding New Delhi metallo-β-lactamase-1 and oxacillinase-58 carbapenemases in Acinetobacter baumannii clinical isolates from a tertiary hospital in Malaysia2026
  5. 5Research progress on bacterial outer membrane vesicles in antibiotic resistance and clinical anti-infective therapy2025 · 14 citations