Safety and efficacy of different local anaesthetics and their concentrations, used for labour pain relief with PCEA for healthy primiparas: a randomized double blind controlled trial

Background: The goal of the study was to evaluate the effectiveness and safety of different low concentrations of local anaesthetics (LCLA) for labour pain relief with PCEA. Materials and Methods: A randomized controlled trial of healthy primiparas was carried out at 2014–2016. Labour pain was relieved with LA and opioid fentanyl (2lg/ml). The patients were allocated into groups according to used LAs and different concentrations: B1-bupivacaine (B)0.0625%, B2-B0.1%, B3-B0.125%, L1-levobupivacaine (L)0.0625%, L2-L0.1%, L3L0.125%. Scale from1 to 10 was used to evaluate the satisfaction. Results: 202 patients were enrolled. Total doses of LA: B1-47(34)mg, B2-73(30)mg, B3–85(58)mg, L1–46(34)mg, L2–74(45)mg, L3–89(48)mg. Total doses significantly differs between groups B1 and B2, B1–L2, B1–L3, B1–B3, L1–L2, L1–L3, L1– B3 (P= 0.028,P= 0.008,P= 0.0001,P= 0.0001, P= 0.039,P= 0.0001,P= 0.0001respectively). For effectiveness of labour pain treatment see the Table. Satisfaction with labour was: B1-10(1), B2-9(1), B3-10(1), L1-10(1), L2-10(1), L3-10(1) (P= 0.132). The rate of motor blockwas: B1-36.7%, B2-58.8%, B3-51.4%, L1-27.3%, L2-31.3%, L3-42.4% (P= 0.074)alsoB-49.5%andL-33.7%(P= 0.017). The incidence of maternal side effects (nausea/ vomiting, itching, shivering, retention of urine, temperature>37°C) doesn’t differ between groups (P= 0.11, P= 0.69, P= 0.79, P= 0.27, P= 0.77 respectively). [...].