What question did this study set out to answer?

The aim is to assess the inhibitory potential of a new hydrazide-hydrazone compound against cholinesterase enzymes in the context of Alzheimer's treatment.

March 1, 2026Cumhuriyet Science JournalOpen Access

Synthesis, BuChE and AChE Enzyme Inhibition and Molecular Docking Studies of Hydrazide-Hydrazone Schiff Base Compound Containing Propargyl/Pyridine Moiety

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Authors

ÖGÖzge GüngörKahramanmaraş Sütçü İmam University

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Implication

Evaluates the inhibitory effects of a Schiff base compound on cholinesterase enzymes, implying potential for Alzheimer's treatment.

Key Points

The aim is to assess the inhibitory potential of a new hydrazide-hydrazone compound against cholinesterase enzymes in the context of Alzheimer's treatment.
Synthesis and structural characterization of hydrazide-hydrazone Schiff base compound (2a).
Screening for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Determination of IC50 and Ki values for compound 2a compared to the standard drug Galantamine.
Molecular docking studies to evaluate binding interactions.
Compound 2a exhibited IC50 values of 42.72 µM for AChE and 39.19 µM for BuChE.
Compared to Galantamine, compound 2a showed lower activity against AChE and moderate activity against BuChE.
Ki values were identified as 1.25 μM for AChE and 2.32 μM for BuChE.
Molecular docking confirmed strong binding affinity through hydrophilic and hydrophobic interactions.

Cite This Study

Özge Güngör (2026) studied this question.

synapsesocial.com/papers/69a3d800ec16d51705d2e899 https://doi.org/10.17776/csj.1773859

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Synthesis, BuChE and AChE Enzyme Inhibition and Molecular Docking Studies of Hydrazide-Hydrazone Schiff Base Compound Containing Propargyl/Pyridine Moiety

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Cite This Study

Synthesis, BuChE and AChE Enzyme Inhibition and Molecular Docking Studies of Hydrazide-Hydrazone Schiff Base Compound Containing Propargyl/Pyridine Moiety

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Cite This Study

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