What does this research mean for the field?

The ethanolic extract of Putranjiva roxburghii leaves exhibits dose-dependent anxiolytic effects in rat models, comparable to diazepam. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the anxiolytic effects of the ethanolic extract of Putranjiva roxburghii leaves in rat models.

March 1, 2026Open Access

Investigation of Anxiolytic Potential of Ethanolic Extract of Putranjiva Roxburghii Wall Leaves in Rat Models

View Full Paper

Ask AI

Bookmark

Authors

RKRohan K. M.*, Dr. Nataraj G. R., T. A. Noor Mohammed Khadeer

Discussion

Member takes

Overview

Behavioral and biochemical assessments demonstrate anxiolytic effects in rat models using plant extract, indicating potential for safer anxiety treatments.

Key Points

This research investigates the anxiolytic effects of the ethanolic extract of Putranjiva roxburghii leaves in rat models.
Prepared ethanolic extract using Soxhlet extraction with a yield of 20.6%
Conducted behavioral tests: Elevated Plus Maze (EPM), Open Field Test (OFT), Head-Dipping Test (HBT), and Rotarod test
Administered different doses of the extract (250 mg/kg and 500 mg/kg) and compared to a standard (diazepam)
Measured monoamine oxidase (MAO) activity and lipid peroxidation post-treatment
High dose (500 mg/kg) improved open arm exploration in the EPM and head-dipping behavior in the HBT compared to control
Both doses increased time spent in the central zone of the OFT and reduced muscle rigidity in the rotarod test
Biochemical analysis showed dose-dependent reductions in MAO activity and lipid peroxidation, indicating antioxidative potential

Cite This Study

Rohan K. M.*, Dr. Nataraj G. R., T. A. Noor Mohammed Khadeer (2026) studied this question.

synapsesocial.com/papers/69a3d830ec16d51705d2ed07 https://doi.org/10.5281/zenodo.18797313

View Full Paper

Ask AI

Bookmark

March 1, 2026Open Access

Investigation of Anxiolytic Potential of Ethanolic Extract of Putranjiva Roxburghii Wall Leaves in Rat Models

View Full Paper

Ask AI

Bookmark

Authors

RKRohan K. M.*, Dr. Nataraj G. R., T. A. Noor Mohammed Khadeer

Discussion

Member takes

Overview

Behavioral and biochemical assessments demonstrate anxiolytic effects in rat models using plant extract, indicating potential for safer anxiety treatments.

Key Points

This research investigates the anxiolytic effects of the ethanolic extract of Putranjiva roxburghii leaves in rat models.
Prepared ethanolic extract using Soxhlet extraction with a yield of 20.6%
Conducted behavioral tests: Elevated Plus Maze (EPM), Open Field Test (OFT), Head-Dipping Test (HBT), and Rotarod test
Administered different doses of the extract (250 mg/kg and 500 mg/kg) and compared to a standard (diazepam)
Measured monoamine oxidase (MAO) activity and lipid peroxidation post-treatment
High dose (500 mg/kg) improved open arm exploration in the EPM and head-dipping behavior in the HBT compared to control
Both doses increased time spent in the central zone of the OFT and reduced muscle rigidity in the rotarod test
Biochemical analysis showed dose-dependent reductions in MAO activity and lipid peroxidation, indicating antioxidative potential

Cite This Study

Rohan K. M.*, Dr. Nataraj G. R., T. A. Noor Mohammed Khadeer (2026) studied this question.

synapsesocial.com/papers/69a3d830ec16d51705d2ed07 https://doi.org/10.5281/zenodo.18797313

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark