What question did this study set out to answer?

To explore the effects of probiotics and omega-3 fatty acids on inflammation in chronic colitis.

March 1, 2026LOGIKA Jurnal Pendidikan Matematika

Combined Therapy with Probiotic VSL#3 and Omega-3 Fatty Acids Attenuates Colonic Injury and Inflammation in Chronic DNBS-induced Colitis in Mice

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Investigating combined therapy reduces inflammation in chronic colitis, suggesting a new treatment strategy.

To explore the effects of probiotics and omega-3 fatty acids on inflammation in chronic colitis.
Induced colitis in BALB/c mice using 2,4-Dinitrobenzenesulfonic acid (DNBS).
Divided mice into treatment groups: control, VSL#3, omega-3, and combined therapy.
Administered treatments for 10 days and assessed inflammation and intestinal damage.
Control colitis group showed significantly higher levels of inflammatory markers (IFN-gamma, IL-17, TNF-alpha).
Microscopic damage scores were lower in the combined therapy group compared to control and mono-treatment groups.
Histological results indicated the closest resemblance to non-colitis control in the combined therapy group.

Toğay et al. (2021) studied this question.

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