What question did this study set out to answer?

The aim is to evaluate the diagnostic value of anti-endomysial antibody (EMA) testing alongside tissue transglutaminase (TTG) antibodies for coeliac disease diagnosis.

March 1, 2026Frontline Gastroenterology

Anti-endomysial antibody detection is of no benefit as an adjunct to IgA anti-tissue transglutaminase antibodies in the serological diagnosis of coeliac disease

View Full Paper

Ask AI

Bookmark

Authors

AYAlice YauCambridge University Hospitals NHS Foundation Trust RDRachel DaleCambridge University Hospitals NHS Foundation Trust CRC RutterCambridge University Hospitals NHS Foundation Trust

Discussion

Member takes

Implication

Retrospective analysis assesses diagnostic value of EMA in coeliac disease, suggesting it lacks clinical utility.

Key Points

The aim is to evaluate the diagnostic value of anti-endomysial antibody (EMA) testing alongside tissue transglutaminase (TTG) antibodies for coeliac disease diagnosis.
Retrospective analysis of 587 patients tested for TTG and EMA during 2018-2019.
Patients categorized into TTG borderline (7–10 U/mL) and TTG >10 U/mL groups.
Biopsy results used to confirm coeliac disease, and serological thresholds evaluated.
Among borderline cases, 74% of EMA-negative patients had biopsy-confirmed coeliac disease.
In TTG >10 U/mL group, 98% of EMA-positive patients had coeliac disease; however, EMA's sensitivity was low (0.4138).
No significant association found between EMA and biopsy results (p=0.7341), indicating limited diagnostic benefit.

Cite This Study

Yau et al. (2026) studied this question.

synapsesocial.com/papers/69a3d830ec16d51705d2ee48 https://doi.org/10.1136/flgastro-2025-103344

View Full Paper

Ask AI

Bookmark

Anti-endomysial antibody detection is of no benefit as an adjunct to IgA anti-tissue transglutaminase antibodies in the serological diagnosis of coeliac disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Anti-endomysial antibody detection is of no benefit as an adjunct to IgA anti-tissue transglutaminase antibodies in the serological diagnosis of coeliac disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider