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Synapse
March 1, 20260 citationsOpen Access

Life-Threatening Amlodipine Shock Reversed Within Hours: A Case Demonstrating the Hyperinsulemic Euglycemic Therapy

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1R1Dr. Meenakumari, 2Dr. Zakeena, 3*Dr. Kani Revanth

Key Points

  • The aim is to demonstrate the effectiveness of hyperinsulemic euglycemic therapy in treating amlodipine overdose shock.
  • Case report of a male patient with altered mental status after amlodipine overdose.
  • Utilized inotropes and high-dose insulin therapy in the emergency department.
  • Monitored the patient's response to treatment in real-time.
  • The patient's circulatory shock was reversed within hours after initiating insulin therapy.
  • Significant improvement in myocardial metabolism was observed as treatment progressed.

Abstract

Amlodipine, a dihydropyridine calcium channel blocker, is primarily prescribed for managing essential hypertension and angina pectoris. An overdose of calcium channel blockers can lead to severe hypotension and shock. We report a case of a 45-year-old male who was brought to the emergency department with altered mental status and shock after ingesting 200 mg of amlodipine. The patient’s circulatory shock was managed with inotropes and high-dose insulin therapy can restore myocardial metabolism and save lives.

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Cite This Study

1Dr. Meenakumari, 2Dr. Zakeena, 3*Dr. Kani Revanth (2026) studied this question.

synapsesocial.com/papers/69a3d8b8ec16d51705d2fc69https://doi.org/10.5281/zenodo.18796142
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium channel blocker overdose in real world practice: A case report2025
  2. 2C49-41 Pressure Cooker: Managing Shock in Amlodipine Overdose2026
  3. 3Massive Amlodipine Overdose Complicated by Multiorgan Failure and Cardiac Arrest: A Case Report2025 · 5 citations
  4. 4Effective Management of Severe Amlodipine/Atenolol Overdose with Intravenous Calcium, Hyperinsulinemic Euglycemia Therapy, and Continuous Veno-Venous Hemodialysis: A Case Report2024 · 4 citations
  5. 5Life‐Threatening Amlodipine Overdose: A Rare Case of Noncardiogenic Pulmonary Edema and Respiratory Failure Requiring ICU Care2025 · 1 citations