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March 1, 2026Science Immunology

Human LFA-1 governs T cell immune surveillance of the skin

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Authors

AYAhmad YatimInsermLYLeila YoussefianCity Of Hope National Medical CenterAIAida IdaniInserm

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Implication

Observational analysis reveals LFA-1's critical role in T cell immune surveillance in skin, suggesting its importance in controlling papillomavirus infections.

Key Points

  • This research aims to understand the role of LFA-1 in T cell migration and immune response in the skin.
  • Assessment of LFA-1 deficiency in adults with skin lesions
  • Analysis of leukocyte subset development and function
  • Evaluation of T cell migration and skin-tropic memory T cell behavior
  • Complete LFA-1 deficiency leads to impaired migration of CLA+ memory T cells to the skin
  • Patients exhibited skin lesions linked to papillomavirus without invasive infections
  • Alternative integrins support the migration of other leukocytes to different tissues

Cite This Study

Yatim et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8caec16d51705d2ffc7https://doi.org/10.1126/sciimmunol.adz8360
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural Basis of Integrin Regulation and Signaling2007 · 1,672 citations
  2. 2α4 integrins and the immune response2002 · 146 citations
  3. 3Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.1981 · 283 citations
  4. 4Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus2003 · 38 citations