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March 1, 2026

Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.

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Authors

ZWZiyue WangSLSixuan LuYMYan Ma

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Overview

This review explores the toxic effects of microplastics in environmental toxicology, suggesting crucial implications for human health.

Key Points

  • To understand the toxicological effects of microplastics using metabolomics and to elucidate underlying mechanisms.
  • Reviewed metabolomic methodologies related to environmental toxicology.
  • Synthesize evidence of multisystem toxic effects of microplastics.
  • Summarized integration of metabolomic data with multiomics to uncover mechanisms.
  • Microplastics induce systemic toxicity through metabolic disruptions in specific organs.
  • In the gut, they impair barrier integrity and cause significant metabolic reprogramming.
  • They disrupt neurotransmitter metabolism in the nervous system, affecting cognitive functions.
  • Microplastics alter reproductive metabolism, reducing sperm quality and fetal growth.
  • Central energy metabolism pathways like glycolysis are inhibited, impairing growth across species.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8caec16d51705d30003https://doi.org/10.1002/jat.70077
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