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December 22, 2010New England Journal of Medicine

Apixaban versus Enoxaparin for Thromboprophylaxis after Hip Replacement

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Why the study?

Does apixaban reduce venous thromboembolism in patients undergoing hip replacement?

Population

Patients undergoing hip replacement

Comparison

Apixaban vs Enoxaparin

Design

RCT

Authors

MLMichael R. LassenUniversity of CopenhagenAGAlexander GallusSouth Australia PathologyGRGary E. RaskobVascular Medicine

Discussion

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Implication

Apixaban may be preferred for VTE prophylaxis after hip replacement; extends randomized evidence for DOACs in orthopedic surgery.

Key Points

  • To compare the efficacy and safety of apixaban versus enoxaparin for thromboprophylaxis in patients undergoing hip replacement surgery.
  • Clinical trial evaluating thromboprophylaxis regimens (ClinicalTrials.gov number, NCT00423319) in patients undergoing hip replacement.
  • Patients received either apixaban or enoxaparin to evaluate rates of post-surgical venous thromboembolism and major bleeding events.
  • Apixaban administration resulted in lower rates of venous thromboembolism compared to enoxaparin.
  • The reduction in thromboembolic events with apixaban occurred without an associated increase in bleeding complications.

Structured PICO

Does apixaban reduce venous thromboembolism in patients undergoing hip replacement?

P
Population
Patients undergoing hip replacement
I
Intervention
Apixaban
C
Comparator
Enoxaparin
O
Outcome
Venous thromboembolismhard clinical

Apixaban provides superior thromboprophylaxis against venous thromboembolism compared to enoxaparin following hip replacement, without an increased risk of bleeding.

Cite This Study

Lassen et al. (2010) studied this question.

synapsesocial.com/papers/69a49ddb2c251382ac68c8ddhttps://doi.org/10.1056/nejmoa1006885
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