Key result
Alpha-SMA and calponin expression peaks at embryonic day 14, marking regional maturation in rat cardiomyocytes.
Why the study?
To establish if alpha-smooth-muscle actin, calponin, and desmin contribute to the specific functional properties of early cardiomyocytes by studying their spatiotemporal expression pattern.
Population
Prenatal and neonatal Wistar rats
Design
Preclinical laboratory study
Authors
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Should not yet change clinical practice; extends prior myofibrillar development studies as maturation markers.
Alpha-SMA, calponin, and desmin are involved in myofibrillar development in the rat heart, with their spatiotemporal expression patterns serving as markers for regional cardiomyocyte maturation.
Ya et al. (1997) studied this question. Expression of smooth-muscle proteins alpha-SMA and calponin peaks at embryonic day 14 then declines, marking regional maturation timing in prenatal rat cardiomyocytes.
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