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This review aims to systematically explore the mechanisms of ferroptosis and its interaction with the tumor immune microenvironment.

March 2, 2026Frontiers in ImmunologyOpen Access

Ferroptosis reshapes the tumor immune microenvironment: molecular mechanisms, immune regulation, and therapeutic synergistic strategies

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This review examines ferroptosis mediating immune regulation in cancer, highlighting its therapeutic potential and challenges.

This review aims to systematically explore the mechanisms of ferroptosis and its interaction with the tumor immune microenvironment.
Systematic review of literature on ferroptosis mechanisms and immune regulation.
Analysis of signaling pathways like NRF2, p53, and Hippo-YAP.
Discussion of therapeutic strategies for inducing ferroptosis in cancer.
Ferroptosis influences immune cell function, notably CD8+ T cells and macrophages.
Inducing ferroptosis can help overcome drug resistance and inhibit tumor metastasis.
Combination strategies with immunotherapy may enhance therapeutic efficacy.

Lv et al. (2026) studied this question.

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