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To investigate the occurrence of localized bullous pemphigoid following surgical trauma in an elderly patient.

March 2, 2026CureusOpen Access

Localized Bullous Pemphigoid Triggered by Surgical Trauma: A Case Highlighting the Koebner Phenomenon

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To investigate the occurrence of localized bullous pemphigoid following surgical trauma in an elderly patient.
Reported case of a 90-year-old woman with localized BP after orthopedic surgery.
Histological examination of skin lesions was performed.
Immunofluorescence analysis for C3 deposition and circulating anti-BP180 antibodies was conducted.
Topical corticosteroid therapy was initiated for treatment.
Localized BP developed along the surgical scar one month post-surgery.
Histology showed a subepidermal blister with eosinophils.
Immunofluorescence confirmed C3 deposition and presence of anti-BP180 antibodies.
Clinical improvement noted after starting topical corticosteroid therapy.

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Case reports localized bullous pemphigoid following surgical trauma, suggesting trauma can trigger autoimmune responses.

Ouahab et al. (2026) studied this question.

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