What question did this study set out to answer?

To report a rare presentation of generalized bullous pemphigoid triggered by a closed skeletal fracture without skin breakage in an elderly patient.

August 19, 2026Case Reports in DermatologyOpen Access

Exacerbation of Bullous Pemphigoid Following a Closed Bone Fracture in an Elderly Patient: A Case Report

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To report a rare presentation of generalized bullous pemphigoid triggered by a closed skeletal fracture without skin breakage in an elderly patient.
Evaluated an 85-year-old female who presented with widespread tense bullae three months following a closed left radius fracture.
Conducted histopathological analysis, direct immunofluorescence for IgG and C3 deposition, and ELISA for anti-BP180 autoantibodies.
Histopathology and immunofluorescence confirmed subepidermal blistering with eosinophils and linear IgG/C3 deposition along the dermo-epidermal junction, alongside high anti-BP180 titers.
Systemic prednisone therapy initiated at 90 mg/day led to blister cessation within two weeks and complete clinical remission within three weeks.

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Implication

Case report demonstrates generalized bullous pemphigoid following a closed bone fracture in an 85-year-old patient, suggesting internal skeletal trauma can trigger autoimmune blistering.

Cite This Study

Azanbayeva et al. (2026) studied this question.

synapsesocial.com/papers/6a8563fe03308d306e2d78a8 https://doi.org/10.1159/000553401

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Implication

Case report demonstrates generalized bullous pemphigoid following a closed bone fracture in an 85-year-old patient, suggesting internal skeletal trauma can trigger autoimmune blistering.

Exacerbation of Bullous Pemphigoid Following a Closed Bone Fracture in an Elderly Patient: A Case Report

Key Points

Discussion

Implication

Cite This Study

Exacerbation of Bullous Pemphigoid Following a Closed Bone Fracture in an Elderly Patient: A Case Report

Key Points

Discussion

Implication

Cite This Study

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