What question did this study set out to answer?

This research aimed to compare the effectiveness of aloe vera gel, sitagliptin, and glibenclamide for treating diabetes in rat models.

March 2, 2026International Journal of PharmacologyOpen Access

Comparative Study of Natural Aloe vera Gel, Sitagliptin and Glibenclamide as D iabetes Medications on Streptozotocin-Induced Male Rat Models

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Authors

AHAhlam Abbas HarasaniUniversity of Jeddah RSRokayya SamiTaif University RARasha A. Al-EisaTaif University

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Implication

Comparative study evaluates diabetes effects of aloe vera gel, sitagliptin, and glibenclamide in diabetic rat models, suggesting aloe vera gel's superior antioxidant benefits.

Key Points

This research aimed to compare the effectiveness of aloe vera gel, sitagliptin, and glibenclamide for treating diabetes in rat models.
Used 60 male albino Wistar rats divided into six groups.
Administered treatments for 3 weeks and measured body weights and fasting blood glucose levels.
Conducted blood analyses on fat profiles and biochemical enzymes.
Analyzed data using SPSS with post hoc tests for significance.
Aloe vera gel treatment significantly reduced fasting blood glucose levels to 100.01 mg/dL.
The STZ+AG and STZ+GLIB group reported similar hemoglobin values.
The STZ+GLIB group exhibited the lowest insulin resistance and beta-cell values at 46.73 and 474.02.
Aloe vera gel enhanced the antioxidant defense system more effectively than the other medications.

Cite This Study

Harasani et al. (2026) studied this question.

synapsesocial.com/papers/69a52dd3f1e85e5c73bf0ee6 https://doi.org/10.31083/ijp44189

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Implication

Comparative study evaluates diabetes effects of aloe vera gel, sitagliptin, and glibenclamide in diabetic rat models, suggesting aloe vera gel's superior antioxidant benefits.

Comparative Study of Natural Aloe vera Gel, Sitagliptin and Glibenclamide as D iabetes Medications on Streptozotocin-Induced Male Rat Models

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparative Study of Natural Aloe vera Gel, Sitagliptin and Glibenclamide as D iabetes Medications on Streptozotocin-Induced Male Rat Models

Discussion

Member takes

Implication

Key Points

Cite This Study

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