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The research aimed to evaluate the effectiveness of Azanza garckeana fruit extract on blood glucose and glycated haemoglobin levels in diabetic rats.

Changes in Blood Glucose and Glycosylated Haemoglobin Levels in Alloxan-Induced Diabetic Female Wistar Rats Treated with Azanza garckeana Fruit Extract

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Experimental study reveals Azanza garckeana extract lowers blood glucose in diabetic rats, suggesting a potential herbal treatment strategy.

The research aimed to evaluate the effectiveness of Azanza garckeana fruit extract on blood glucose and glycated haemoglobin levels in diabetic rats.
Induced diabetes using alloxan via injection in Wistar rats.
Divided 30 rats into control and treatment groups: alloxan only, various doses of AGF, and glibenclamide.
Measured blood glucose levels at multiple intervals over 28 days using a glucometer.
Assessed glycated haemoglobin on the 28th day.
Blood glucose levels rose significantly in alloxan-only rats from 4.34 to 18.26 mmol/L by day 1.
HbA1 levels increased from 4.10% in the control to 4.64% in the alloxan group.
The 500mg/kg AGF extract reduced blood glucose to 5.94 mmol/L by day 28.
HbA1 decreased to 4.08% with 1000mg/kg AGF extract, showing significant improvement.

Laz-Okenwa et al. (2026) studied this question.

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Experimental study reveals Azanza garckeana extract lowers blood glucose in diabetic rats, suggesting a potential herbal treatment strategy.