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February 5, 2026Open Access

Antihyperglycemic and metabolic regulatory effects of Artemisia vulgaris L. in alloxan-induced diabetic female wistar rats

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Authors

PEPatricia Ene EjembiJOJames Agada OcheLZLongchi Satkat Zacchaeus

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Overview

Investigates the antihyperglycemic effects of Artemisia vulgaris in diabetic rats, suggesting it may aid in diabetes management.

Key Points

  • The research aimed to evaluate the effects of Artemisia vulgaris on glucose regulation and metabolic dysfunction in alloxan-induced diabetic Wistar rats.
  • Induced diabetes using alloxan monohydrate in Wistar rats
  • Divided rats into six treatment groups including a control
  • Administered A. vulgaris extract orally once daily for 30 days
  • Measured fasting blood glucose, serum lipid profile, serum proteins, and renal and liver markers post-treatment
  • Alloxan significantly decreased body weight and HDL-C, while increasing fasting blood glucose, liver enzymes, and total cholesterol
  • A. vulgaris treatment improved body weight from 161.0 g to 259.7 g and decreased fasting blood glucose from 4.09 mmol/L to 3.68 mmol/L
  • Lipid profile and organ function markers showed significant improvement, with the 400 mg/kg dose being as effective as standard antidiabetic drugs.

Cite This Study

Ejembi et al. (2026) studied this question.

synapsesocial.com/papers/6984360af1d9ada3c1fb594bhttps://doi.org/10.5281/zenodo.18467535
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Artemisia vulgaris Extract as a Novel Therapeutic Approach for Reversing Diabetic Cardiomyopathy in a Rat Model2024 · 6 citations
  2. 2Changes in Blood Glucose and Glycosylated Haemoglobin Levels in Alloxan-Induced Diabetic Female Wistar Rats Treated with Azanza garckeana Fruit Extract2026
  3. 3Effects of Ethanolic Extract of Cyperus esculentus (Tiger Nut) Tubers on Blood Glucose Level and Lipid Profile in Alloxan-Induced Diabetes Mellitus in Male Wistar Rats2024 · 1 citations
  4. 4Effects of Ethanolic Lyophilized and Nanoparticle Extracts of Cilo Wormwood (Artemisia haussknechtii Boiss.) Leaves on Histopathological Findings Antioxidant Defence System and Serum Biomarker Constituents in Diabetic Rats2026
  5. 5Aqueous Artemisia herba-alba Asso Preparation as a Botanical Adjunct to Dapagliflozin: Enhanced Glycemic Control in Streptozotocin-Induced Diabetic Rats2026