What does this research mean for the field?

Artemisia haussknechtii leaf extracts, particularly in nanoparticle formulation, significantly reduce hyperglycemia, oxidative stress, and tissue damage in experimental diabetic rat models. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study investigates how extracts from Artemisia haussknechtii leaves affect diabetes-related oxidative stress and biomarkers in rats.

June 6, 2026Applied Biochemistry and BiotechnologyOpen Access

Effects of Ethanolic Lyophilized and Nanoparticle Extracts of Cilo Wormwood (Artemisia haussknechtii Boiss.) Leaves on Histopathological Findings Antioxidant Defence System and Serum Biomarker Constituents in Diabetic Rats

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MİMusa İşnasVan Yüzüncü Yıl Üniversitesi İÇİsmail ÇelikVan Yüzüncü Yıl Üniversitesi BBBedia BatıVan Yüzüncü Yıl Üniversitesi

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Overview

Randomized trial evaluates Artemisia haussknechtii extracts' effects on oxidative stress and biomarkers in diabetic rats, suggesting potential therapeutic benefits.

Key Points

The study investigates how extracts from Artemisia haussknechtii leaves affect diabetes-related oxidative stress and biomarkers in rats.
48 female rats were divided into six groups and induced with diabetes using STZ (45 mg/kg, i.p.).
Rats received oral doses of ethanolic lyophilized extract (DYEE) and nanoparticle extract (DYNE) at 50 and 100 mg/kg for 21 days.
Fasting glucose, body weight, serum biochemistry, and oxidative stress markers were measured alongside histopathological evaluations of tissues.
Diabetic rats exhibited hyperglycemia, body weight loss, dyslipidemia, and increased oxidative stress markers like MDA and TOS.
Treatment with high-dose nanoparticle formulation (DYNE2) resulted in significant improvements in blood glucose, lipid profile, and antioxidant parameters.
Histopathological evaluation indicated reduced diabetes-induced tissue damage, particularly in the DYNE2 group.

Cite This Study

İşnas et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb2071a5da9775e76b21 https://doi.org/10.1007/s12010-026-05751-5

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June 6, 2026Applied Biochemistry and BiotechnologyOpen Access

Effects of Ethanolic Lyophilized and Nanoparticle Extracts of Cilo Wormwood (Artemisia haussknechtii Boiss.) Leaves on Histopathological Findings Antioxidant Defence System and Serum Biomarker Constituents in Diabetic Rats

View Full Paper

Ask AI

Bookmark

Authors

MİMusa İşnasVan Yüzüncü Yıl Üniversitesi İÇİsmail ÇelikVan Yüzüncü Yıl Üniversitesi BBBedia BatıVan Yüzüncü Yıl Üniversitesi

Discussion

Member takes

Overview

Randomized trial evaluates Artemisia haussknechtii extracts' effects on oxidative stress and biomarkers in diabetic rats, suggesting potential therapeutic benefits.

Key Points

The study investigates how extracts from Artemisia haussknechtii leaves affect diabetes-related oxidative stress and biomarkers in rats.
48 female rats were divided into six groups and induced with diabetes using STZ (45 mg/kg, i.p.).
Rats received oral doses of ethanolic lyophilized extract (DYEE) and nanoparticle extract (DYNE) at 50 and 100 mg/kg for 21 days.
Fasting glucose, body weight, serum biochemistry, and oxidative stress markers were measured alongside histopathological evaluations of tissues.
Diabetic rats exhibited hyperglycemia, body weight loss, dyslipidemia, and increased oxidative stress markers like MDA and TOS.
Treatment with high-dose nanoparticle formulation (DYNE2) resulted in significant improvements in blood glucose, lipid profile, and antioxidant parameters.
Histopathological evaluation indicated reduced diabetes-induced tissue damage, particularly in the DYNE2 group.

Cite This Study

İşnas et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb2071a5da9775e76b21 https://doi.org/10.1007/s12010-026-05751-5

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