Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population

Q: What does this research mean for the field?

Tirzepatide and semaglutide lead to significant weight loss at 6 months in a subgroup of highly persistent and adherent Medicaid members. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Katelyn Meyer; Mckenzie McVeigh; Ashley N. Chiara; Kaelyn C. Boss; Thomas C. Pomfret; Kyle Semmel; Rachel Bacon; Diala Nicolas; Karen M. Clements; Caroline J. Alper; Kimberly Lenz

doi:10.18553/jmcp.2026.32.3.271

February 28, 2026Journal of Managed Care & Specialty Pharmacy

Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population

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Key Points

This research aims to assess the persistence and adherence to GLP-1 medications and their weight loss effectiveness in a Medicaid population over six months.
Analyzed MassHealth members' adherence to GLP-1 and GLP-1/GIP treatments over six months.
Measured weight loss outcomes among highly persistent and adherent participants.
Evaluated the effectiveness of tirzepatide and semaglutide in the studied population.
At six months, participants showed moderate persistence and adherence to GLP-1 treatment.
Significant weight loss was observed among members who were highly persistent and adherent.
Tirzepatide and semaglutide were found effective in the weight loss efforts of those participants.

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Implication

Observational study evaluates weight loss outcomes of GLP-1 medications in Medicaid members, suggesting effective management of obesity.

Abstract

At 6 months, MassHealth members showed moderate persistence and adherence to GLP-1 or GLP-1/GIP treatment. Tirzepatide and semaglutide were effective in producing significant weight loss at 6 months among a subgroup of highly persistent and adherent members.

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Cite This Study

Meyer et al. (2026) studied this question.

synapsesocial.com/papers/69a52e45f1e85e5c73bf1c22 https://doi.org/10.18553/jmcp.2026.32.3.271

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Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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