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March 2, 2026

Topical Imiquimod for Oral Cavity Leukoplakia and Dysplasia: A Scoping Review.

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Authors

MSMegan K. ScharnerAWAngelica M. WalkerSNShaun A Nguyen

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Overview

Scoping review demonstrates efficacy of topical imiquimod in reducing lesions in oral cavity dysplasia, suggesting a new treatment avenue.

Key Points

  • This review aims to evaluate the effectiveness of topical imiquimod in treating oral cavity leukoplakia and dysplasia.
  • Conducted a scoping review of existing literature on topical imiquimod.
  • Analyzed cases reporting on lesion size reduction and complete resolution.
  • Assessed adverse effects associated with treatment.
  • Topical imiquimod showed significant reduction in lesion size.
  • Complete resolution of lesions was achieved in some cases.
  • Minimal adverse effects were reported.

Cite This Study

Scharner et al. (2026) studied this question.

synapsesocial.com/papers/69a52e64f1e85e5c73bf20behttps://doi.org/10.1002/ohn.70107
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Imiquimod: A Off-Label Drug in the Management of Oral Homogeneous Leukoplakia: A Pilot Study2025
  2. 2Imiquimod for the treatment of oral leukoplakia: A two‐center retrospective study2024 · 10 citations
  3. 3Imiquimod for Melanoma in Situ and Lentigo Maligna: A Systematic Review2026
  4. 4Laser Therapy Versus Conventional Treatments in Oral Leukoplakia: A Systematic Review of Efficacy, Recurrence, and Postoperative Outcomes2026 · 3 citations
  5. 5Management of Oral Leukoplakia – A Systematic Umbrella Review of Global Evidence2024