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August 1, 2015Circulation Cardiovascular Interventions

Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Nobori Stent Implantation in Patients With Non–ST-Segment–Elevation Myocardial Infarction (OCTACS) Trial

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Why the study?

Does OCT-guided percutaneous coronary intervention with biolimus-eluting stent implantation improve strut coverage at 6 months in patients with NSTEMI compared to angiographic guidance alone?

Population

100 patients with non-ST-segment-elevation myocardial infarction (NSTEMI)

Comparison

Optical coherence tomography-guided percutaneous… vs Angiographic guidance only for percutaneous…

Design

RCT, 1:1

Follow-up

6 months

Authors

LALisbeth AntonsenPTPer ThayssenAMAkiko Maehara

Discussion

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Overview

OCT guidance may reduce late thrombosis risk via better healing in NSTEMI; extends randomized evidence for imaging optimization over angiography.

Structured PICO

Does OCT-guided percutaneous coronary intervention with biolimus-eluting stent implantation improve strut coverage at 6 months in patients with NSTEMI compared to angiographic guidance alone?

P
Population
100 patients with non-ST-segment-elevation myocardial infarction (NSTEMI)
I
Intervention
Optical coherence tomography (OCT)-guided percutaneous coronary intervention with biolimus-eluting stent implantation
C
Comparator
Angiographic guidance only for percutaneous coronary intervention with biolimus-eluting stent implantation
O
Outcome
Strut coverage at 6 monthssurrogate

OCT-guided PCI optimization improves stent strut coverage at 6 months compared to angiography alone, potentially reducing the risk of later thrombotic events.

Cite This Study

Antonsen et al. (2015) studied this question.

synapsesocial.com/papers/69a5f9d7f28036b4e899dc6ehttps://doi.org/10.1161/circinterventions.114.002446
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial2010 · 40 citations
  2. 2Intravascular ultrasound-guided optimized stent deployment Immediate and 6 months clinical and angiographic results from the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study)1998 · 470 citations
  3. 3Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance2014 · 204 citations
  4. 4Pathological Correlates of Late Drug-Eluting Stent Thrombosis2007 · 1,276 citations
  5. 5Third Universal Definition of Myocardial Infarction2012 · 2,645 citations