Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Nouhoum Dibo; Zhijun Zhou; Xianshu Liu; Zhuolin Li; Shukun Zhong; Jiajing Zhang; Huilan Wang; Bo Li; Xiaohui Yang; Yuehui Li; Xiang Wu; Shuaiqin Huang

doi:10.3389/fcimb.2025.1739541

January 27, 2026Frontiers in Cellular and Infection MicrobiologyOpen Access

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

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Key Points

Innate and adaptive immune responses were activated in Microtus fortis at 10 dpi, contrasting with Kunming mice.
The analysis reveals a distinct transcriptome profile of immune cells during infection progression at 10 dpi.
Single-cell RNA-sequencing of peripheral blood mononuclear cells allows insight into immune dynamics in detail.
This study highlights key differences between rodent models, which may inform future research on immunity.

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Implication

Single-cell RNA-sequencing reveals immune response activation in Microtus fortis at 10 dpi, indicating important immune dynamics.

Abstract

Together, our results suggest that both the innate and adaptive immune responses were activated in the peripheral blood of M. fortis at 10 dpi, while their activation was not obvious in Kunming mice at the same moment.

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Dibo et al. (2026) studied this question.

synapsesocial.com/papers/69a75ac3c6e9836116a20fd2 https://doi.org/10.3389/fcimb.2025.1739541

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Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Key Points

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Implication

Abstract

Discussion

Cite This Study

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Key Points

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Implication

Abstract

Discussion

Cite This Study

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