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Phase I study uncovers significant heterogeneity in PSMA expression on CTCs, suggesting further assessment is needed.
While EC1169 showed limited activity, CTC and imaging analyses showed significant heterogeneity in PSMA expression on CTCs in patients with predominantly PSMA-positive lesions on SPECT. Our study highlights the importance of assessing both PSMA-based CTC and imaging assays in future validation trials.
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Zaidi et al. (2026) studied this question.
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