Why the study?
Recent studies suggest offspring of pregnancies affected by preeclampsia may have an increased risk for cardiovascular disease due to fetal programming, prompting a focus on their cardiometabolic risks.
Does in utero exposure to preeclampsia increase cardiometabolic risk in offspring?
Does in utero exposure to preeclampsia increase cardiometabolic risk in offspring?
This review highlights the potential increased cardiometabolic risk in offspring exposed to preeclampsia in utero due to fetal programming.
May support enhanced cardiometabolic monitoring in exposed offspring; reinforces fetal programming hypothesis and warrants longitudinal studies.
Preeclampsia is a hypertensive disorder that occurs during pregnancy, affecting 3-5% of pregnancies globally and is an independent cardiovascular risk factor for the mother, and recent studies reveal that offspring of affected pregnancies may also have an increased risk for developing cardiovascular diseases (Karrar and Hong, 2022). This is referred to as foetal programming and is said to be related to several factors (Davies et al., 2017). Therefore, this study focuses on the cardiometabolic risks endured by offspring of preeclamptic pregnancies.
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Mabuto et al. (2026) studied this question.
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