What does this research mean for the field?

In utero exposure to preeclampsia increases the risk of offspring developing cardiometabolic and cardiovascular diseases later in life through fetal programming. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

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March 3, 2026Open Access

In Utero Exposure to Preeclampsia and Cardiometabolic Risk: A Review of Literature

Key Points

Cardiometabolic risks significantly increase in offspring exposed to preeclampsia during pregnancy, indicating serious health concerns.
Preeclampsia affects 3-5% of pregnancies worldwide, contributing to potential cardiovascular issues for both mothers and children.

Structured PICO

Does in utero exposure to preeclampsia increase cardiometabolic risk in offspring?

Population

Offspring of preeclamptic pregnancies

Intervention

In utero exposure to preeclampsia

Outcome

Cardiometabolic risks

This review highlights the potential increased cardiometabolic risk in offspring exposed to preeclampsia in utero due to fetal programming.

Abstract

Preeclampsia is a hypertensive disorder that occurs during pregnancy, affecting 3-5% of pregnancies globally and is an independent cardiovascular risk factor for the mother, and recent studies reveal that offspring of affected pregnancies may also have an increased risk for developing cardiovascular diseases (Karrar and Hong, 2022). This is referred to as foetal programming and is said to be related to several factors (Davies et al., 2017). Therefore, this study focuses on the cardiometabolic risks endured by offspring of preeclamptic pregnancies.

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