Key result
Carotid wall shear stress outperforms CIMT for predicting high ASCVD risk with ~0.87 AUC.
Why the study?
Abnormal wall shear stress is associated with endothelial dysfunction and atherosclerosis, but its relationship with ASCVD risk stratification using vector flow mapping is unclear.
Does carotid wall shear stress measured by vector flow mapping improve prediction of very high or ultrahigh ASCVD risk compared to carotid intima-media thickness in a Chinese population?
Cross-Sectional (n=155)
No
Does carotid wall shear stress measured by vector flow mapping improve prediction of very high or ultrahigh ASCVD risk compared to carotid intima-media thickness in a Chinese population?
Carotid wall shear stress measured noninvasively by vector flow mapping outperforms traditional carotid intima-media thickness for identifying patients at very high or ultrahigh ASCVD risk.
Answers are grounded in this paper and cite their sources.
May aid ASCVD risk stratification beyond intima-media thickness; hypothesis-generating and requires prospective validation before practice change.
Background: Wall shear stress (WSS) is affected by a variety of hemodynamic factors and plays a role in the pathogenesis of many diseases, such as abnormal WSS is associated with local endothelial dysfunction and atherosclerosis (AS). Vector flow mapping (VFM) is a new tool developed to calculate WSS according to the mass conservation equation. The aim of this study was to evaluate the association between carotid WSS measured by the VFM technique and atherosclerotic cardiovascular disease (ASCVD) risk stratification. Methods: A retrospective analysis was conducted on 155 individuals who were recruited from the Department of Cardiology at Qilu Hospital of Shandong University. Carotid WSS was measured via the VFM technique. The correlations between carotid intima-media thickness (CIMT) or ASCVD risk stratification and carotid WSS were assessed via Spearman analysis. Multiple linear regression was used to examine the correlation between traditional risk factors or biochemical indicators and carotid WSS. Receiver operating characteristic (ROC) analysis was performed to analyze the association between carotid WSS and ASCVD risk stratification. Results: for predicting very high or ultrahigh risk of ASCVD was larger than of CIMT (all P values <0.05). Conclusions: Carotid WSS measured with the VFM technique was significantly correlated with CIMT and ASCVD risk stratification and could be used for screening and monitoring individuals with potential ASCVD risk.
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Zhao et al. (2026) conducted a cross-sectional in Atherosclerotic cardiovascular disease (ASCVD) risk (n=155). Carotid wall shear stress (WSS) measured by vector flow mapping vs. Carotid intima-media thickness (CIMT) was evaluated on Predicting very high or ultrahigh risk of ASCVD (AUC) (AUC 0.866 vs 0.756, p=0.001). Mean carotid wall shear stress measured by vector flow mapping showed superior predictive value for very high or ultrahigh ASCVD risk compared to carotid intima-media thickness.
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