Key result
Average systolic common carotid artery wall shear stress was correlated with brachial-ankle pulse wave velocity in subjects with subclinical atherosclerosis.
Why the study?
Changes in vascular wall shear stress lead to artery wall remodeling that may increase arterial stiffness, prompting investigation into the association between ba-PWV and carotid wall shear stress measured by vascular vector flow mapping.
Does common carotid artery wall shear stress measured by vector flow mapping correlate with brachial-ankle pulse wave velocity and 10-year cardiovascular disease risk in subjects free of apparent cardiovascular disease?
Cross-Sectional (n=94)
No
Does common carotid artery wall shear stress measured by vector flow mapping correlate with brachial-ankle pulse wave velocity and 10-year cardiovascular disease risk in subjects free of apparent cardiovascular disease?
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for shear stress as arterial stiffness marker; should not yet change practice in subclinical atherosclerosis.
Objective Arterial stiffness is an important tissue biomarker of the progression of atherosclerotic diseases. Brachial-ankle pulse wave velocity (ba-PWV) is a gold standard of arterial stiffness measurement widely used in Asia. Changes in vascular wall shear stress (WSS) lead to artery wall remodeling, which could give rise to an increase in arterial stiffness. The study aimed to explore the association between ba-PWV and common carotid artery (CCA) WSS measured by a newly invented vascular vector flow mapping (VFM) technique. Methods We included 94 subjects free of apparent cardiovascular disease (CVD) and divided them into a subclinical atherosclerosis (SA) group ( N = 47) and non subclinical atherosclerosis (NSA) group ( N = 47). CCA WSS was measured using the VFM technique. Bivariate correlations between CCA WSS and other factors were assessed with Pearson's, Spearman's, or Kendall's coefficient of correlation, as appropriate. Partial correlation analysis was conducted to examine the influence of age and sex. Multiple linear stepwise regression was used for the analysis of independent determinants of CCA WSS. Receiver operating characteristic (ROC) analysis was performed to find the association between CCA WSS and 10-year CVD risk. Results The overall subjects had a mean age of 47.9 ± 11.2 years, and males accounted for 52.1%. Average systolic CCA WSS was significantly correlated with ba-PWV ( r = −0.618, p < 0.001) in the SA group. Multiple linear stepwise regression analysis confirmed that ba-PWV was an independent determinant of average systolic CCA WSS ( β = −0.361, p = 0.003). The area under the curve (AUC) of average systolic CCA WSS for 10-year CVD risk ≥10% was 0.848 ( p < 0.001) in the SA group. Conclusions Average systolic CCA WSS was significantly correlated with ba-PWV and was associated with 10-year CVD risk ≥10% in the SA group. Therefore, CCA WSS measured by the VFM technique could be used for monitoring and screening subjects with potential CVD risks.
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Cheng et al. (2023) conducted a cross-sectional in Subclinical atherosclerosis (n=94). Common carotid artery wall shear stress (CCA WSS) vs. Non-subclinical atherosclerosis was evaluated on Correlation between average systolic CCA WSS and ba-PWV in the subclinical atherosclerosis group (r = -0.618, p=<0.001). Average systolic common carotid artery wall shear stress was correlated with brachial-ankle pulse wave velocity in subjects with subclinical atherosclerosis.
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