Key result
Baseline brachial-ankle pulse wave velocity ≥ 1,400 cm/s was independently associated with a 52% increased risk of new carotid plaque formation (OR 1.52) compared to < 1,400 cm/s.
Why the study?
Does elevated baseline brachial-ankle pulse wave velocity (≥1,400 cm/s) predict new carotid plaque formation in a community-based population without baseline plaques?
Cohort (n=738)
No
Does elevated baseline brachial-ankle pulse wave velocity (≥1,400 cm/s) predict new carotid plaque formation in a community-based population without baseline plaques?
Odds Ratio: 1.52 (95% CI 1.02–2.25)
Absolute Event Rate: 36.5% vs 21.2%
p-value: p=0.04
Elevated baseline brachial-ankle pulse wave velocity (≥1,400 cm/s) is an independent predictor of new carotid plaque formation, suggesting its utility as an early marker for atherosclerosis risk.
Supports baPWV in observational risk assessment; leaves open whether stiffness reduction prevents plaque.
Artery stiffness is an independent marker for atherosclerotic cardiovascular diseases. However, whether the brachial-ankle pulse wave velocity (ba-PWV) is related to new carotid plaque formation is unresolved. This study aimed to investigate the association between baseline ba-PWV and new carotid plaque formation in a Chinese community-based population without carotid plaques at baseline. This study population consisted of a total of 738 participants from an atherosclerosis cohort in Beijing, China. After a mean 2.3-year follow-up, the incidence of carotid plaques were 21.2% and 36.5% in the groups with ba-PWV < 1,400 cm/s and ≥1,400 cm/s, respectively. Compared with baseline ba-PWV < 1,400 cm/s group, ba-PWV ≥ 1,400 cm/s group was significantly associated with the incidence of new carotid plaque formation (odds ratio [OR] = 2.14, 95% CI: 1.50-3.03, P < 0.01), even after adjusting for common risk factors (OR = 1.52, 95% CI: 1.02-2.25, P = 0.04). Furthermore, there was a strong relationship between baseline ba-PWV and carotid plaque formation in subjects with ba-PWV < 1,400 cm/s, but no such relationship was found in subjects with baseline ba-PWV ≥ 1,400 cm/s. In conclusion, this study suggests that baseline ba-PWV is independently associated with the risk of carotid plaque formation in a Chinese community-based population.
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Yang et al. (2018) conducted a cohort in Carotid plaque formation (n=738). Baseline ba-PWV ≥ 1,400 cm/s vs. Baseline ba-PWV < 1,400 cm/s was evaluated on Incidence of new carotid plaque formation (OR 1.52, 95% CI 1.02-2.25, p=0.04). Baseline brachial-ankle pulse wave velocity ≥ 1,400 cm/s was independently associated with a 52% increased risk of new carotid plaque formation (OR 1.52) compared to < 1,400 cm/s.
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