Key result
Brachial-ankle and carotid-femoral pulse wave velocity were positively associated with 10-year ASCVD risk, with every 1 m/s increase raising risk by 0.60% and 1.17%, respectively (p<.001).
Why the study?
Carotid-femoral and brachial-ankle PWV predict cardiovascular events, but whether their predictive ability is equivalent remains unclear.
Are brachial-ankle and carotid-femoral pulse wave velocities associated with the 10-year risk of ASCVD in a Chinese community-based population?
Cross-Sectional (n=5,282)
No
Are brachial-ankle and carotid-femoral pulse wave velocities associated with the 10-year risk of ASCVD in a Chinese community-based population?
Effect estimate: 0.60% increase per 1 m/s increase in baPWV (95% CI 0.56-0.65)
p-value: p=<.001
Both brachial-ankle and carotid-femoral pulse wave velocities are positively and comparably associated with the 10-year risk of ASCVD in a Chinese community-based population.
baPWV and cfPWV associate with higher 10-year ASCVD risk; leaves open incremental predictive value beyond standard factors in prospective studies.
Accumulated evidence has shown that carotid-femoral and brachial-ankle PWV well predict cardiovascular events but it is still unclear if the predictability is same or not. In this cross-sectional study based on a community atherosclerosis cohort in Beijing, China, a total of 5282 participants without previous coronary heart disease and stroke were enrolled from a community atherosclerosis cohort in Beijing, China. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk were calculated by the China-PAR model, and < 5%, 5%-10% and > 10% were defined as low, intermediate, and high risk, respectively. The average baPWV and cfPWV values were 16.63 ± 3.35 m/s and 8.45 ± 1.78 m/s, respectively. The mean 10-year ASCVD risk was 6.98% (interquartile range: 3.90%-12.01%). The patients with low, intermediate, and high 10-year ASCVD risk accounted for 34.84% (1840), 31.94% (1687),, and 33.23% (1755) respectively. Multivariate analysis showed that for every 1 m/s increase in baPWV and cfPWV, the 10-year ASCVD risk increased by 0.60% (95% confidence interval: 0.56%-0.65%, p < .001) and 1.17% (95% confidence interval: 1.09%-1.25%, p < .001), respectively. The diagnostic ability of the baPWV was comparable to the cfPWV (area under the curve: 0.870 [0.860-0.879] vs. 0.871 [0.861-0.881], p = .497). In conclusion, baPWV and cfPWV are positively associated with the 10-year risk of ASCVD in the Chinese community-based population, with a nearly identical association with a high 10-year risk of ASCVD.
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Yi et al. (2023) conducted a cross-sectional in atherosclerotic cardiovascular disease (ASCVD) risk (n=5,282). Pulse wave velocity (baPWV and cfPWV) was evaluated on 10-year ASCVD risk (0.60% increase per 1 m/s increase in baPWV, 95% CI 0.56-0.65, p=<.001). Brachial-ankle and carotid-femoral pulse wave velocity were positively associated with 10-year ASCVD risk, with every 1 m/s increase raising risk by 0.60% and 1.17%, respectively (p<.001).
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