Key result
baPWV, unlike cfPWV, is linked to new-onset major cardiovascular events.
Why the study?
While cfPWV is the gold standard for arterial stiffness, baPWV is increasingly applied in Asian populations, prompting a comparison of their associations with new-onset cardiovascular events.
Does baPWV compared to cfPWV better predict the risk of new-onset cardiovascular events in a community-based Asian population?
Cohort (n=5,723)
No
Does baPWV compared to cfPWV better predict the risk of new-onset cardiovascular events in a community-based Asian population?
In a Chinese community-based cohort, baPWV was a robust predictor of incident cardiovascular events, outperforming the gold-standard cfPWV, suggesting it may be a more practical tool for routine risk assessment in Asian populations.
Answers are grounded in this paper and cite their sources.
baPWV was associated with events independent of risk factors while cfPWV was not; hypothesis-generating for Asian cohorts and should not yet change practice.
Carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) are widely used indicators of arterial stiffness, with cfPWV considered the gold standard and baPWV increasingly applied in Asian populations. In this community-based cohort from Beijing, we compared the associations of cfPWV and baPWV with the risk of new-onset cardiovascular events. A total of 5723 residents from the Shougang community with available cfPWV and baPWV measurements from the 2018 follow-up survey were included. CfPWV was measured using Pulsepen and baPWV using the Omron BP-203RPE III device. Cardiovascular events, defined as a composite outcome of cardiovascular death, first-ever myocardial infarction, or stroke, were identified from national and municipal registries through December 31, 2021. Over a median follow-up of 3.15 years, 173 cardiovascular events occurred. Both cfPWV and baPWV were associated with incident cardiovascular events in Kaplan-Meier analyses. However, in multivariable Cox regression models adjusting for traditional cardiovascular risk factors, cfPWV showed a nonsignificant trend (p = 0.072), while baPWV remained significantly associated with new-onset events (p < 0.001). These findings indicate that in this community-based population, baPWV, but not cfPWV, demonstrates a robust association with cardiovascular risk, suggesting that baPWV may serve as a more practical and effective tool for routine cardiovascular risk assessment in Asian populations.
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Gao et al. (2026) reported a cohort. Brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV) was evaluated on Composite outcome of cardiovascular death, first-ever myocardial infarction, or stroke (p=<0.001). Brachial-ankle pulse wave velocity (baPWV) was associated with new-onset cardiovascular events, whereas carotid-femoral pulse wave velocity (cfPWV) was not.
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