Key result
Brachial-ankle pulse wave velocity demonstrated a significant positive correlation with central aortic pulse wave velocity measured by cardiovascular magnetic resonance (r=0.697, p<0.001).
Why the study?
The usefulness and reliability of brachial-ankle pulse wave velocity (BA-PWV) to measure aortic stiffness lacked supporting data compared to cardiovascular magnetic resonance (CMR).
Does brachial-ankle pulse wave velocity (BA-PWV) correlate with cardiovascular magnetic resonance (CMR) for measuring aortic stiffness in participants without cardiovascular risk factors?
Cross-Sectional (n=124)
Blinded outcome assessment
No
Does brachial-ankle pulse wave velocity (BA-PWV) correlate with cardiovascular magnetic resonance (CMR) for measuring aortic stiffness in participants without cardiovascular risk factors?
Effect estimate: r=0.697
p-value: p=<0.001
Brachial-ankle pulse wave velocity is a reliable and simple surrogate for central aortic stiffness, correlating well with CMR measurements regardless of age and sex.
BA-PWV correlates with CMR aortic PWV and distensibility; supports its role as a simple stiffness surrogate but leaves broader validation open.
PURPOSE: Despite technical simplicity and the low cost of brachial-ankle pulse wave velocity (BA-PWV), its use has been hampered by a lack of data supporting its usefulness and reliability. The aim of this study was to evaluate the usefulness of BA-PWV to measure aortic stiffness in comparison to using cardiovascular magnetic resonance (CMR). MATERIALS AND METHODS: A total of 124 participants without cardiovascular risk factors volunteered for this study. BA-PWV was measured using a vascular testing device. On the same day, using CMR, cross-sectional areas for distensibility and average blood flow were measured at four aortic levels: the ascending, upper thoracic descending, lower thoracic descending, and abdominal aorta. RESULTS: Compared to PWV measured by CMR, BA-PWV values were significantly higher and the differences therein were similar in all age groups (all p<0.001). There was a significant correlation between BA-PWV and PWV by CMR (r=0.697, p<0.001). Both BA-PWV and PWV by CMR were significantly and positively associated with age (r=0.652 and 0.724, p<0.001). The reciprocal of aortic distensibility also demonstrated a statistically significant positive correlation with BA-PWV (r=0.583 to 0.673, all p<0.001). CONCLUSION: BA-PWV was well correlated with central aortic PWV and distensibility, as measured by CMR, regardless of age and sex.
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Kim et al. (2015) conducted a cross-sectional in Healthy volunteers without cardiovascular risk factors (n=124). Brachial-ankle pulse wave velocity (BA-PWV) vs. Cardiovascular magnetic resonance (CMR) was evaluated on Correlation between BA-PWV and central aortic PWV measured by CMR (r=0.697, p=<0.001). Brachial-ankle pulse wave velocity demonstrated a significant positive correlation with central aortic pulse wave velocity measured by cardiovascular magnetic resonance (r=0.697, p<0.001).
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