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January 1, 2010Journal of Atherosclerosis and ThrombosisOpen Access

Brachial-ankle Pulse Wave Velocity as an Index of Central Arterial Stiffness

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Why the study?

Does brachial-ankle pulse wave velocity (baPWV) accurately reflect central arterial stiffness compared to aortic PWV?

Population

2,806 consecutive participants in a non-invasive vascular laboratory, excluding those with an ankle-brachial…

Comparison

Measurement of brachial-ankle pulse wave velocity vs Measurement of heart-femoral, heart-carotid…

Design

Cross-sectional

Authors

STShoko TsuchikuraInoue HospitalTSTetsuo ShojiVascular MedicineEKEiji KimotoKinan Hospital

Discussion

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Implication

baPWV may reflect central stiffness similarly to hfPWV; leaves open its incremental value for risk prediction in prospective studies.

Key Points

  • To determine whether automated brachial-ankle pulse wave velocity primarily reflects the stiffness of central or peripheral arteries.
  • Evaluated 2,806 consecutive vascular laboratory participants, excluding individuals with an ankle-brachial index lower than 0.95.
  • Simultaneously measured pulse wave velocity across brachial-ankle, heart-femoral (aorta), heart-carotid, heart-brachial, and femoral-ankle segments using an automated device.
  • Conducted correlational analyses among segmental velocities, individual cardiovascular risk factors, and the Framingham risk score.
  • baPWV showed its highest correlation with heart-femoral aortic PWV (r=0.796) and its lowest with heart-carotid PWV (r=0.541).
  • Elevated baPWV was closely associated with recognized central arterial risk factors, specifically advanced age, diabetes mellitus, and chronic kidney disease.
  • Framingham risk score correlated more strongly with heart-femoral PWV (r=0.613) and baPWV (r=0.609) than with heart-brachial (r=0.523), heart-carotid (r=0.509), or femoral-ankle PWV (r=0.393).

Structured PICO

Does brachial-ankle pulse wave velocity (baPWV) accurately reflect central arterial stiffness compared to aortic PWV?

P
Population
2,806 consecutive participants in a non-invasive vascular laboratory, excluding those with an ankle-brachial index (ABI) lower than 0.95.
I
Intervention
Measurement of brachial-ankle pulse wave velocity (baPWV)
C
Comparator
Measurement of heart-femoral (hf, aorta), heart-carotid (hc), heart-brachial (hb), and femoral-ankle (fa) PWV
O
Outcome
Correlation among different regional pulse wave velocity valuessurrogate

Brachial-ankle pulse wave velocity is a valid surrogate index for central arterial stiffness, showing similar characteristics and risk factor correlations to aortic PWV.

Cite This Study

Tsuchikura et al. (2010) studied this question.

synapsesocial.com/papers/6a7162e7a528af2d65c40cc7https://doi.org/10.5551/jat.3616
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness2009 · 592 citations
  2. 2Cut-Off Value of the Ankle-Brachial Pressure Index at Which the Accuracy of Brachial-Ankle Pulse Wave Velocity Measurement is Diminished2004 · 97 citations
  3. 3Preferential Stiffening of Central Over Peripheral Arteries in Type 2 Diabetes2003 · 220 citations
  4. 4Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients2001 · 3,870 citations
  5. 5Regional Arterial Stiffness Associated with Ischemic Heart Disease in Type 2 Diabetes Mellitus2006 · 54 citations