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March 3, 2026Movement Disorders8 citationsOpen Access

Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha‐Synuclein Seed Amplification Assay

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SBSarah M. BrookerNorthwestern UniversityJPJacopo PasquiniUniversity of PisaSCSeung Ho ChoiUniversity of Iowa

Key Points

  • Participants with negative alpha-synuclein assay have lower hyposmia rates, indicating potential variations in the disease presentation.
  • About 14% of SAA- participants experienced a change in diagnosis during the study, highlighting diagnostic uncertainty.
  • Participants were assessed on clinical characteristics like hyposmia and brain imaging for subcortical atrophy.
  • Findings suggest further investigation into the implications of subcortical brain atrophy for diagnosis and treatment.

Abstract

At baseline, SAA- sPD PPMI participants have a substantially lower rate of hyposmia, but otherwise cannot be readily distinguished from SAA+ participants based on clinical characteristics. However, SAA- participants have a greater degree of subcortical brain atrophy, and approximately one out of seven SAA- participants received a change in diagnosis. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Cite This Study

Brooker et al. (2026) studied this question.

synapsesocial.com/papers/69a75bfac6e9836116a2441ehttps://doi.org/10.1002/mds.70197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence and Pathology of Synucleinopathies and Tauopathies Related to Parkinsonism2013 · 199 citations
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  3. 3Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease2014 · 413 citations
  4. 4Lewy bodies and parkinsonism in families with parkin mutations2001 · 484 citations
  5. 5Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study2023 · 727 citations