Although the detection of biomarkers epinephrine (EP) and homovanillic acid (HO) is critical for early diagnosis and personalized medicine, the development of a luminescent sensor for their precise quantification remains an ongoing challenge. In this work, a unique porous Hf6-based metal-organic framework (MOF), Hf6(μ3-O)4(μ3-OH)4(OH)4(H2O)4(PPTA)2·xS (denoted as 1), with high acid stability was synthesized. It serves as a dual-function luminescence sensor for EP and HO detection, achieving low limits of detection of 9.3 × 10-9 and 1.8 × 10-7 mol/L, respectively. Besides, the thin film 1@CRG can be simply synthesized for visual detection of EP and HO, demonstrating great potential for home-testing use. This work presents a new MOF-based sensing platform, paving the way for advanced multianalyte biomarker detection in clinical diagnostics.
Dong et al. (Wed,) studied this question.