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January 29, 2026Nature Reviews Genetics

High-throughput identification of aptamer–target pairs with SPARK-seq

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Key Points

Aptamer-target pairs were successfully identified through a high-throughput sequencing approach, enhancing interaction mapping.
Key metrics include a significant increase in the efficiency of aptamer-based selections resulting from the SPARK-seq method.
Observational analysis with advanced sequencing techniques enables rapid identification of specific aptamers for desired targets.
This approach highlights the potential for broader applications in therapeutic and diagnostic settings, possibly transforming molecular analysis.

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Implication

High-throughput method identifies aptamer-target pairs, suggesting improved molecular interaction mapping.

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Cite This Study

Qin Wu (2026) studied this question.

synapsesocial.com/papers/69a75d88c6e9836116a27ac3 https://doi.org/10.1038/s41576-026-00938-2

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