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December 1, 2025Journal of the Neurological Sciences

Combining onabotulinumtoxina and CGRP monoclonal antibodies in chronic migraine: A systematic review

Adinda Aisya Kamila Timothy Chong Tissa Wijeratne

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Key Points

Combining onabotulinumtoxina and CGRP monoclonal antibodies shows improved outcomes in chronic migraine treatment.
Meta-analysis of various studies reveals significant reductions in headache frequency when using both therapies together.
Observational analysis of treatment effects highlights efficacy in patients unresponsive to standard treatments.
Results suggest further investigation into this dual therapy is warranted for chronic migraine management.

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Implication

Systematic review evaluates combining two migraine treatments, indicating potential benefits for chronic migraine patients.

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Cite This Study

Kamila et al. (2025) studied this question.

synapsesocial.com/papers/69a75f50c6e9836116a2a9a7 https://doi.org/10.1016/j.jns.2025.124179

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