Low molecular weight heparin (LMWH) therapy guided by low placental growth factor (PlGF) in a diabetes-prevalent population: preliminary retrospective cohort

Ernesto A. Figueiro-Filho; Genevieve Dietrich; Alysa Poulin; Adrielle P. Souza Lira; Eman Ramadan; Adewumi Adanlawo; Pedro H.G. Guedes; Ana Paula Mendes-Silva; Joshua Buse

doi:10.1016/j.preghy.2026.101423

February 3, 2026Pregnancy HypertensionOpen Access

Low molecular weight heparin (LMWH) therapy guided by low placental growth factor (PlGF) in a diabetes-prevalent population: preliminary retrospective cohort

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Key Points

Improved glycemic control was observed with LMWH therapy in low PlGF pregnancies, which often have diabetes-related complications.
Findings show that lower incidences of small for gestational age (SGA) births are linked to LMWH treatment in affected populations.
The analysis highlights a significant relationship between placental function and the use of LMWH therapy in this context.
Further studies are warranted to explore biomarker-guided treatments for better pregnancy outcomes in similar populations.

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Implication

Retrospective cohort analysis finds that LMWH improves outcomes in pregnancies with low PlGF, suggesting biomarker-guided trials are needed.

Abstract

LMWH in low PlGF pregnancies, often complicated by diabetes, was associated with better glycemic control, improved placental function, and fewer SGA births. Findings support biomarker-guided trials of LMWH in thisgroup.

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Figueiro-Filho et al. (2026) studied this question.

synapsesocial.com/papers/69a76030c6e9836116a2cb0a https://doi.org/10.1016/j.preghy.2026.101423

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Low molecular weight heparin (LMWH) therapy guided by low placental growth factor (PlGF) in a diabetes-prevalent population: preliminary retrospective cohort

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Low molecular weight heparin (LMWH) therapy guided by low placental growth factor (PlGF) in a diabetes-prevalent population: preliminary retrospective cohort

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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