Key result
Single-application pulsed field ablation rapidly terminates AF originating from persistent left superior vena cava.
Why the study?
Does Pulsed Field Ablation (PFA) safely and effectively terminate atrial fibrillation triggered by a persistent left superior vena cava?
Case Report (n=1)
No
Does Pulsed Field Ablation (PFA) safely and effectively terminate atrial fibrillation triggered by a persistent left superior vena cava?
This case demonstrates that a circular array pulsed field ablation catheter can safely and effectively target and terminate atrial fibrillation triggered by non-pulmonary vein foci such as a persistent left superior vena cava.
Suggests PFA feasibility for persistent left superior vena cava-triggered AF; hypothesis-generating and requires prospective validation.
A 73-year-old patient with paroxysmal atrial fibrillation (AF) and a history of two ablation procedures was referred to our center due to recurrence. Persistent left superior vena cava (PLSVC) was revealed in preprocedural echocardiography and computed tomography. A circular array Pulsed Field Ablation (PFA) catheter was applied for the re-intervention. Incessant AF was induced during the procedure. PFA successfully terminated AF within the distal part of PLSVC, where high-frequency fragmented electrograms were found, demonstrating the efficacy of circular array PFA catheter for the ablation within PLSVC.
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Xie et al. (2026) conducted a case report in Paroxysmal atrial fibrillation with persistent left superior vena cava (n=1). Circular array Pulsed Field Ablation (PFA) catheter was evaluated on Termination of atrial fibrillation. A single application of pulsed field ablation using a circular array catheter successfully terminated atrial fibrillation originating from the distal persistent left superior vena cava.
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