Answers are grounded in this paper and cite their sources.
Case report demonstrates negative uptake of 68Ga-FAPI-04 in HNF-1α mutated hepatocellular adenoma, suggesting diagnostic implications.
A 37-year-old woman was incidentally found to have a hepatic lesion on ultrasound. Serum tumor markers, including AFP, CEA, and CA19-9, were normal. Gd-EOB-DTPA-enhanced MRI revealed a fat-containing lesion with arterial phase hyperenhancement, rapid washout, hypointensity in the hepatobiliary phase, and no diffusion restriction, making it difficult to differentiate between hepatic adenoma (HCA) and small hepatocellular carcinoma (HCC). 18 F-FDG PET/CT revealed intense uptake, raising suspicion of malignancy, while 68 Ga-FAPI-04 PET/CT demonstrated negligible uptake. Histopathology confirmed hepatocyte nuclear factor 1α (HNF1α)-mutated hepatocellular adenoma (H-HCA). This case may provide valuable insights into differentiating H-HCA from small HCC.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: