A case report reveals high FAPI uptake and low FDG uptake in hepatic epithelioid hemangioendothelioma, suggesting diagnostic benefits of FAPI imaging.
We report a rare case of multifocal hepatic epithelioid hemangioendothelioma (HEHE) evaluated using [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET/CT. Abdominal CT revealed multiple hepatic masses with mild peripheral enhancement and central necrosis. On [¹⁸F]FDG PET/CT, the lesions demonstrated uptake similar to or faint compared with normal liver parenchyma, whereas [⁶⁸Ga]Ga-FAPI-04 PET/CT showed intense tracer accumulation with a high tumor-to-background ratio in all hepatic lesions, without evidence of extrahepatic involvement. This case illustrates the potential diagnostic advantage of FAPI imaging in detecting and characterizing hepatic vascular tumors with low FDG avidity.
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YERDEŞ et al. (2026) studied this question.
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