Case reports show FDG PET detects primary splenic angiosarcoma and liver metastases better than FAPI PET.
A few case reports show FAPI PET may be superior to FDG PET in evaluating angiosarcoma. We describe FDG PET/CT, delayed abdominal FDG PET/MRI, and 18F-FAPI-04 PET/CT findings in a case of primary splenic angiosarcoma with diffuse hepatic metastases. In this case, FDG PET was superior to FAPI PET in evaluating the primary and metastatic tumors. FDG PET showed much higher activity in the primary splenic tumors compared with 18F-FAPI-04 PET. FDG PET identified the hepatic metastases due to increased activity, which was missed on 18F-FAPI-04 PET.
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Li et al. (2026) studied this question.
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