Abstract Scaling-up municipal biowaste conversion technologies to industrial levels is essential for advancing clean and sustainable technologies and addressing significant technical, economic, and environmental challenges associated with urban organic waste management. Studies that explore technological gaps across the upstream, midstream, and downstream processing stages of biorefineries are critical for transforming biowaste into value-added products. This study aims to fill these gaps through a systematic literature review following the PRISMA guidelines and utilizing the Technology Readiness Level (TRL), which enabled the selection of 88 cases subsequently analyzed using descriptive and content analysis. The main findings show that anaerobic digestion has achieved full commercial maturity (TRL 9), while acidogenic fermentation remains mostly at TRL 6–7, and other pathways such as microbial protein or holocellulase production are still at early stages (TRL 3–4). High-value products, including polyhydroxyalkanoates (PHA) and succinic acid, are clustered at TRL 6–7, typically demonstrated at pilot scale, whereas hydrochar from hydrothermal carbonization has progressed up to TRL 8–9. Companies and projects confirm the feasibility of integrating biological, chemical, and thermal pathways into biorefineries, spanning a wide range of TRLs and showcasing their potential within the circular bioeconomy. Key gaps persist in scaling downstream processes for product purification, reducing costs, addressing feedstock variability, and optimizing pretreatment. By synthesizing experimental evidence with industrial demonstrations and sustainability assessments, this study provides a comprehensive perspective on how municipal biowaste can be converted into both non-fuel bioproducts and biofuels, thereby supporting circular bioeconomy strategies for future environmental policies. Graphical Abstract
Cerdán et al. (Mon,) studied this question.