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This study aims to compare the effectiveness of brain-derived pTau217 and total pTau217 in diagnosing Alzheimer's disease pathology.

Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification

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A head-to-head comparison demonstrates BD-pTau217's superior classification of Alzheimer's disease pathology in clinical assessments.

This study aims to compare the effectiveness of brain-derived pTau217 and total pTau217 in diagnosing Alzheimer's disease pathology.
Utilized NULISAqpcr BD-pTau217 assay and Simoa ALZpath total pTau217 assay.
Conducted in two independent Chinese cohorts characterized by amyloid-PET.
Analyzed correlations with blood levels of urea and creatinine.
BD-pTau217 exhibited a strong correlation with total pTau217 (ρ = 0.89 to 0.90).
Showed reduced interference from kidney dysfunction compared to total pTau217.
BD-pTau217 had a higher area under the curve (AUC = 0.96 to 0.98) for amyloid-β pathology classification.

Jiang et al. (2026) studied this question.

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