What question did this study set out to answer?

The aim is to evaluate treatment outcomes for primary squamous cell carcinoma of the urethra based on a long-term institutional experience.

Primary urethral squamous cell carcinoma: Insights and outcomes from a 27-year institutional experience.

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Retrospective review shows favorable overall survival for primary urethral SCC, suggesting a need for clearer care standards.

The aim is to evaluate treatment outcomes for primary squamous cell carcinoma of the urethra based on a long-term institutional experience.
Conducted a retrospective review of an IRB-approved urethral cancer database.
Identified patients using ICD-10 and ICD-9 codes for primary urethral carcinoma.
Analyzed data on demographics, treatments, and outcomes over 27 years.
Included various treatments like chemotherapy and surgical interventions.
Identified 35 patients (51.5%) with primary SCC out of 68 primary urethral cancer cases.
5-year recurrence free survival rate was 56.8%, and overall survival rate was 93.8%.
Neoadjuvant chemotherapy was administered to 45.7% of patients, primarily using gemcitabine-based regimens.
Common surgical procedures included urethrectomy (N=12), penectomy (N=8), and radical cystectomy (N=7).
Notable primary metastatic sites included lymph nodes and regional genitourinary areas.

Zahir et al. (2026) studied this question.

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View Full Paper

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Authors

Retrospective review shows favorable overall survival for primary urethral SCC, suggesting a need for clearer care standards.

The aim is to evaluate treatment outcomes for primary squamous cell carcinoma of the urethra based on a long-term institutional experience.
Conducted a retrospective review of an IRB-approved urethral cancer database.
Identified patients using ICD-10 and ICD-9 codes for primary urethral carcinoma.
Analyzed data on demographics, treatments, and outcomes over 27 years.
Included various treatments like chemotherapy and surgical interventions.
Identified 35 patients (51.5%) with primary SCC out of 68 primary urethral cancer cases.
5-year recurrence free survival rate was 56.8%, and overall survival rate was 93.8%.
Neoadjuvant chemotherapy was administered to 45.7% of patients, primarily using gemcitabine-based regimens.
Common surgical procedures included urethrectomy (N=12), penectomy (N=8), and radical cystectomy (N=7).
Notable primary metastatic sites included lymph nodes and regional genitourinary areas.

Zahir et al. (2026) studied this question.

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